منابع مشابه
Are relatives of patients with multiple HNPCC spectrum tumours at increased risk of cancer?
BACKGROUND Relatives of patients with early onset colorectal cancer, a feature of hereditary non-polyposis colorectal cancer (HNPCC), are at increased risk of colorectal cancer. AIMS To investigate risk in relatives of patients with multiple primary cancers, another feature of HNPCC. METHODS Details were obtained on patients from one region who had developed colorectal cancer and a separate...
متن کاملLynch syndrome (HNPCC)
Lynch syndrome, also referred to as hereditary non-polyposis colorectal cancer (HNPCC), accounts for somewhere between 2 and 5% of all CRC. It has been shown that Lynch syndrome (LS) is a result of germline mutations in genes involved in DNA mismatch repair (MMR) MSH2, MLH1, MSH6, and PMS2, whereas as HNPCC refers to families that adhere to the Amsterdam criteria or iterations of it. More recen...
متن کاملComplex genetic predisposition to cancer in an extended HNPCC family with an ancestral hMLH1 mutation.
Hereditary non-polyposis colorectal cancer (HNPCC) is characterised by a genetic predisposition to develop colorectal cancer at an early age and, to a lesser degree, cancer of the endometrium, ovaries, urinary tract, and organs of the gastrointestinal tract other than the colon. In the majority of families the disease is linked to mutations in one of the two mismatch repair genes, hMSH2 or hMLH...
متن کاملPapillomaviruses in Multiple Tumours of Twin Goats
In situ hybridisation, polymerase chain reaction as well as L1 antigen immunolabelling indicated the presence of Papillomavirus in tumour samples of twin goats. These findings suggest that caprine PVs may play a role in cutaneous and ocular tumour development, similarly to what has been suggested for humans.
متن کاملExperience of discharge from colonoscopy of mutation negative HNPCC family members.
Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) is an autosomal dominant predisposition for early onset colorectal cancer and other tumours. The mean age at diagnosis of colorectal cancer is about 44 years. At least five genes have been associated with errors in DNA mismatch repair, the genetic basis of HNPCC. A large proportion of HNPCC families (50%–60%) harbour changes i...
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ژورنال
عنوان ژورنال: Gut
سال: 1998
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gut.43.5.596